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10 years ago it was reported that overexpression of the oncogene c-Myc in human epidermal stem cells stimulates differentiation rather than uncontrolled proliferation. This was, understandably, greeted with scepticism by researchers.
Vector-borne viruses are an important class of emerging and re-emerging pathogens; thus, an improved understanding of the cellular factors that modulate infection in their respective vertebrate and insect hosts may aid control efforts.
In a mouse model of the hotspot mutant TP53Y220C, the mutant p53 exhibited oncogenic gain of function in males and teratogenic gain of function in females, both correlated with inflammation.
A. Weinert, R. Blaschke, A. Jeckel, R. Seidemann, J. Urbatschek, F. Rosmann, J. Wanzel, H. Frieb, F. Wirdl, A. Müller, J. Beier, J. Schramm, G. Gabriel 1915.