The age-related dysregulation and decline of the immune system—collectively termed “immunosenescence”—has been generally associated with an increased susceptibility to infectious pathogens and poor vaccine responses in older adults.
Large, elastic arteries are composed of cells and a specialized extracellular matrix that provides reversible elasticity and strength. Elastin is the matrix protein responsible for this reversible elasticity that reduces the workload on the…
The office of High Sheriff of Somerset is an ancient shrievalty which has been in existence since the 11th century. [1 ] Originally known as the "Sheriff of Somerset", the role was retitled on 1 April 1974, under the provisions of the Local…
Nonalcoholic fatty liver disease (Nafld) is becoming increasingly common, currently affecting approximately 37% of US adults. Nafld is most often managed in primary care or endocrine clinics, where clinicians must determine which patients…
Descending facilitation, from the brainstem, promotes spinal neuronal hyperexcitability and behavioural hypersensitivity in many chronic pain states. We have previously demonstrated enhanced descending facilitation onto dorsal horn neurones…