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I am Professor of Paediatrics at Karolinska Institutet since 2011.I am a paediatric oncologist with a special interest in brain tumours. Between 2016 and 2024 I was Vice Head of the Department of Women's and Children's Health.
Apoptosis (―normal‖ or ―programmed‖ cell death) is the physiological process by which unwanted or useless cells are eliminated during development and other normal biological processes.
Exit of cytochrome c from mitochondria into the cytosol has been implicated as an important step in apoptosis. In the cytosol, cytochrome c binds to the CED-4 homologue, Apaf-1, thereby triggering Apaf-1–mediated activation of caspase-9.
NSP 5a3a is a novel structural protein found to be over-expressed in certain cancer cell lines in-vitro such as Hela, Saos-2, and MCF-7 while barely detectable levels in normal body tissues except for Testis.
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