Antibodies to Zika virus (ZIKV) can be protective. To examine the antibody response in individuals that develop high titers of anti-ZIKV antibodies we screened cohorts in Brazil and Mexico for ZIKV envelope domain III (Zediii) binding and…
Fructose-containing added sugars, such as sucrose and high-fructose corn syrup, have been experimentally, epidemiologically, and clinically shown to be involved in the current epidemics of obesity and diabetes.
Type 2 diabetes imposes a large and growing burden on the public’s health. This burden, combined with the growing evidence for primary prevention from randomized controlled trials of structured lifestyle programs leads to recommendations to…
Through high-throughput drug screening, we found that sirtuin inhibitors are potently antiviral against diverse arboviruses, including flaviviruses such as West Nile virus, bunyaviruses such as Rift Valley fever virus, and alphaviruses such…
Alzheimer disease (AD) is the most common cause of dementia in the elderly. Clinicopathological studies support the presence of a long preclinical phase of the disease, with the initial deposition of AD pathology estimated to begin…
Title: Predictors of Immunotherapeutic Benefits in Patients with Advanced Solid Tumors Treated with Immune Checkpoint Inhibitors Sponsor: Orien Foundation PD/PI: Ahmad T. Title: Inherited genetic variation as a predictor of the risk of…
Title: BEST CARE for Recurrent Nmibc: BladdEr-Sparing Therapy and Cystectomy As TREeatments Award Number: 5R01CA289268-02 Sponsor: National Institutes of Health (NIH) Gilbert, S. (PD/PI) Title: Comparison of Intravesical Therapy and Surgery…
Title: Nitric Oxide Immune Dependent Resistance Mechanisms to Anti-PD-1 Therapy Award Number: 5K08CA252164-03 Sponsor: National Cancer Institute (NCI) Markowitz, J. (PD/PI) Title: IFx-Hu2.0 facilitates immune responses in melanoma Award…