In the US, it is solely approved for the treatment of Fibromyalgia even though it is also approved for the treatment of Major depressive disorder (but not Fibromyalgia) in others countries (e.g France)
The drug shows similar affinity for the NMDA receptor as ketamine (Ki = 0.74 and 1.05 μM, respectively). [1 ] It shows analgesic effects in rodents, with about twice the potency of ketamine, and potentiates morphine-induced analgesia. [1…
Levomilnacipran, sold under the brand name Fetzima, is an antidepressant, used for the treatment of major depressive disorder in adults. [4 ] It is the levorotatory enantiomer of milnacipran, and has similar effects and pharmacology, acting…