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Alternative splicing expands the antiviral Ifitm repertoire in…

Author summary Zoonotic transmission occurs when viruses ‘jump’ from animals into human. This may lead to viral outbreaks such as the Covid-19 pandemic, posing a significant threat to public health.
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Recognition and cleavage of human tRNA methyltransferase TRMT1…

The SARS-CoV-2 main protease specifically cleaves a conserved sequence in the human tRNA modifying enzyme TRMT1, resulting in reduced tRNA binding and the complete loss of TRMT1-mediated tRNA methyltransferase activity.
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