There is increasing appreciation of the important role of B cells in many autoimmune diseases and consequently, increasing interest in treating these disorders through B cell-depletion therapy with rituximab, an anti-CD20 monoclonal…
Tissue maintenance and homeostasis can be achieved through replacement of dying cells by differentiating precursors, self-renewal of terminally differentiated cells or relies heavily on cellular longevity in poorly regenerating tissues.
Evidence suggests an important role for gut-microbiota dysbiosis in the development of rheumatoid arthritis (RA). The link between changes in gut bacteria and the development of joint inflammation is missing.
In rheumatoid arthritis (RA), macrophage is one of the major sources of inflammatory mediators. Macrophages produce inflammatory cytokines through toll-like receptor (TLR)-mediated signalling during RA.
Neutrophils serve as a vanguard of the acute innate immune response to invading pathogens. Neutrophils are also abundant at sites of autoimmune inflammation, such as the rheumatoid joint, although their pathophysiologic role is incompletely…
The A6M was usually referred to by its pilots as the Reisen ( 零戦, zero fighter), "0" being the last digit of the imperial year 2600 (1940) when it entered service with the IJN.