The global physiological effects of glucocorticoids are well established, and the framework of transcriptional regulation by the glucocorticoid receptor (GR) has been described. However, the genes directly under GR control that trigger…
MicroRNAs (miRNAs) are small regulatory RNAs that participate in posttranscriptional gene regulation in a sequence-specific manner. However, little is understood about the role(s) of miRNAs in Alzheimer's disease (AD).
Myeloid cells are an abundant leukocyte in many types of tumors and contribute to immune evasion. Expression of the enzyme arginase 1 (Arg1) is a defining feature of immunosuppressive myeloid cells and leads to depletion of L-arginine, a…
The myogenic regulatory factor MRF4 is highly expressed in adult skeletal muscle but its function is unknown. Here we show that Mrf4 knockdown in adult muscle induces hypertrophy and prevents denervation-induced atrophy.
We sought to identify forces shaping the interaction between astrocytes and amyloid-β plaques by performing a spatial analysis, using tools from statistical physics, of 3D images from living transgenic mice.
Alexander II (Russian: Алекса́ндр II Никола́евич, romanized: Aleksándr II Nikoláyevich, IPA: [ɐlʲɪˈksandr ftɐˈroj nʲɪkɐˈlajɪvʲɪtɕ]; 29 April 1818 – 13 March 1881) [a ] was Emperor of Russia, King of Poland and Grand Duke of Finland from 2…
Central Stadium (German: Zentralstadion, pronounced [tsɛnˈtra:lˈʃta:di̯ɔn] ) was a stadium with a capacity of 120,000 in Leipzig which was initially used for matches of SC Rotation Leipzig.