TGF-β attenuates tumour response to PD-L1 blockade by…

Therapeutic antibodies that block the programmed death-ligand 1 (PD-L1)/programmed death-1 (PD-1) pathway can induce robust and durable responses in patients with various cancers, including metastatic urothelial cancer (mUC)1–5.
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Selenium Supplementation Restores Innate and Humoral Immune…

Dietary selenium (Se) alters whole-blood Se concentrations in sheep, dependent upon Se source and dosage administered, but little is known about effects on immune function. We used footrot (FR) as a disease model to test the effects of
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Both a Gauge and a Filter: Cognitive Modulations of Pupil Size…

Over 50 years of research have established that cognitive processes influence pupil size. This has led to the widespread use of pupil size as a peripheral measure of cortical processing in psychology and neuroscience.
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Hereditary cancer syndromes - PMC

Hereditary cancer syndromes (HCSs) are arguably the most frequent category of Mendelian genetic diseases, as at least 2% of presumably healthy subjects carry highly-penetrant tumor-predisposing pathogenic variants (PVs).
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Large Aggregates Are the Major Soluble Aβ Species in AD Brain…

Soluble amyloid-β (Aβ) aggregates of various sizes, ranging from dimers to large protofibrils, have been associated with neurotoxicity and synaptic dysfunction in Alzheimer's Disease (AD).
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Frontiers | Immunotherapy in Lung Cancer: Current Landscape and…

Over the past decade, lung cancer treatment has undergone a major paradigm shift. A greater understanding of lung cancer biology has led to the development o...
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Archivo:Blank.png - Wikipedia, la enciclopedia libre

Blank picture, 3 x 2 pixels; good for a placeholder when you need it to assume a 3:2 aspect ratio. See Image:Blank300.png for a placeholder which won't take up any visible vertical space, and Image:Blank300vert.png for a horizontal one.
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James Grenert | UCSF Profiles

James Grenert's profile, publications, research topics, and co-authors
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Whole-exome sequencing of epithelial ovarian carcinomas…

In addition, distinct mutational signatures, for example, SBS6, and overall mutational load, somatic mutations in Pabpc1, Pabpc3, and TFAM co-segregated with the resistance status, high-grade serous carcinoma subtype, or overall survival of…
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James Robert White PhD

Baltimore, MD | 443.904.6111 | [email protected] | github.com/resphera-jrwhite
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