We tested 310,605 single-nucleotide polymorphisms for association in 778 celiac disease cases and 1422 controls. Outside the HLA, the most significant finding (rs13119723, P=2.0 × 10 −7 , empirical genome-wide significance P=0.045) was in…
Kazuo N. Watanabe currently works at the Gene Research Center, University of Tsukuba. Kazuo does research in Urban/Rural Sociology, Genetics and Botany. Their current project is 'Biodiplomacy'.
The gut microbiota has been typically viewed as an environmental factor for human health. Twins are well suited for investigating the concordance of their gut microbiomes and decomposing genetic and environmental influences.
Obligate scavenging on the dead and decaying animal matter is a rare dietary specialization that in extant vertebrates is restricted to vultures. These birds perform essential ecological services, yet many vulture species have undergone…
Microglia-mediated inflammation is a driving force in Alzheimer’s disease pathogenesis. Spangenberg et al. show that elimination of microglia in 5xfAD mice improves cognitive function and ameliorates synaptic/neuronal loss without altering…
Bacteroidetes are a dominant phylum of the human gut microbiota (HGM) that target otherwise indigestible dietary fiber with an arsenal of polysaccharide utilization loci (PULs), each of which is dedicated to the utilization of a specific…
Alström syndrome is a rare autosomal recessive genetic disorder characterized by cone-rod dystrophy, hearing loss, childhood truncal obesity, insulin resistance and hyperinsulinemia, type 2 diabetes, hypertriglyceridemia, short stature in…
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