The published 95% uncertainty of the global surface air-temperature anomaly (Gsata) record through 1980 is impossibly less than the 2σ = ±0.25 °C lower limit of laboratory resolution of 1 °C/division liquid-in-glass (LiG) thermometers.
A mutation is a sudden heritable change in the DNA in a living cell, not caused by genetic segregation or genetic recombination. Mutation breeding is the purposeful application of mutations in plant breeding.
Gouty arthritis is a very familiar inflammatory arthritis. Controlling inflammation is the key to preventing gouty arthritis. However, colchicine, the most highly represented drug used in clinical practice, has strict contraindications…
The primate dorsolateral prefrontal cortex (Dlpfc) and anterior cingulate cortex (ACC) focus attention on relevant signals and suppress noise in cognitive tasks. However, their synaptic interactions and unique roles in cognitive control are…
Immune checkpoint blockade, exemplified by antibodies targeting the programmed death-1 (PD-1) receptor, can induce durable tumor regressions in some patients. To enhance the efficacy of existing immunotherapies, we screened for small…
The proinflammatory cytokines produced by the innate immune system in response to pathogenic infection protect the host by controlling microbial growth. However, excessive proinflammatory responses could disrupt the host’s vital…
49 discussion posts. Sandy said: If you'd like a place to plan what you'll be reading for the Spring 2012 Challenge, you may post a list in this thread. ...
The human antibody response to flavivirus infection is dominantly directed against a cross-reactive epitope on the fusion loop of domain II (DII-FL) of the envelope (E) protein. Although antibodies against this epitope fail to recognize…