Matrix metalloproteinase (MMP)-1, MMP-8 and MMP-13 are interstitial collagenases that degrade type II collagen in cartilage; this is a committed step in the progression of rheumatoid arthritis and osteoarthritis.
Elizabeth Shown Mills Certified GenealogistSM Certified Genealogical LecturerSM Fellow & Past President, American Society of Genealogists Trustee & Past President, Board for Certification of Genealogists