The resulting cell death results from induced apoptosis or necrosis induced by either membrane disruption or secondary breakdown of the membrane due to transmembrane transfer of electrolytes and adenosine triphosphate. [1 ] [2 ] [3 ] [4…
Bert Vogelstein (born 1949) is director of the Ludwig Center, Clayton Professor of Oncology and Pathology and a Howard Hughes Medical Institute investigator at The Johns Hopkins Medical School and Sidney Kimmel Comprehensive Cancer Center…
Due to the role of aberrant Hedgehog signaling in tumor progression [1 ] [2 ] [3 ] [4 ] [5 ] [6 ] and cancer stem cell maintenance [7 ] [8 ] [9 ] across cancer types, inhibition of the Hedgehog signaling pathway can be a useful strategy for…
Mutations in both RAS and the PTEN/PIK3CA/AKT signaling module are found in the same human tumors. PIK3CA and AKT are downstream effectors of RAS, and the selective advantage conferred by mutation of two genes in the same pathway is unclear…
Ultraviolet radiation (UVR) has numerous effects on skin, including DNA damage, tanning, vitamin D synthesis, carcinogenesis, and immunomodulation. Keratinocytes containing damaged DNA secrete both α-melanocyte-stimulating hormone (α-MSH…
Joe Hippensteel, a Master in Physio-Kinesiology, focuses on Ultimate Human Performance (UHP) at the highest levels. He spent many years training for the Decathlon at a national level.
1561193516807351https://smlouvy.gov.cz/smlouva/168073512021-06-03T14:30:55 02:00afth9xpTechnologická agentura ČR72050365Praha 6, Dejvice, Evropská 1692/37Vysoká škola technická a ekonomická v Českých Budějovicích75081431Okružní, 517/10…