Sirtuins (Sirts) are NAD-dependent deacylases, known to be involved in a variety of pathophysiological processes and thus remain promising therapeutic targets for further validation.
In this review, we will discuss small molecules that recent evidence suggests may be capable of improving health and extending lifespan in mammals, focusing particularly on resveratrol, rapamycin, and metformin.
Adult males average 4 t (4.4 short tons) in weight and females 2.7 t (3.0 short tons). It has a large and well developed neocortex of the brain, is highly intelligent and self-aware being able to display behaviours associated with grief…
Joseph Sriyal Malik Peiris (Sinhala: ජෝසප් ශ්රියාල් මලික් පීරිස්, born 10 November 1949) is a Hong Kong-based Sri Lankan virologist, most notable for being the first person to isolate the SARS virus. [2 ] He is the current Tam Wah-Ching…
As minor planet discoveries are confirmed, they are given a permanent number by the IAU's Minor Planet Center (MPC), and the discoverers can then submit names for them, following the IAU's naming conventions.
Each year, Syncona provides a significant level of philanthropic funding to The Syncona Foundation, which has ambitions aligned to our vision to deliver transformational treatments for patients and through which we believe we contribute to…
The sirtuin system consists of seven highly conserved regulatory enzymes responsible for metabolism, antioxidant protection, and cell cycle regulation. The great interest in sirtuins is associated with the potential impact on life extension…
As minor planet discoveries are confirmed, they are given a permanent number by the IAU's Minor Planet Center (MPC), and the discoverers can then submit names for them, following the IAU's naming conventions.