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The Adaptor Protein of the Anaphase Promoting Complex Cdh1…
The anaphase promoting complex (APC) or cyclosome is a multi-subunit E3 ubiquitin ligase. Cdc20 [fizzy (fzy), or p55CDC] and Cdh1 [Hct1, srw1, or fizzy-related 1 (fzr1)] encode two adaptor proteins that bring substrates to APC.
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UTX and UTY Demonstrate Histone Demethylase-Independent…
UTX (KDM6A) and UTY are homologous X and Y chromosome members of the Histone H3 Lysine 27 (H3K27) demethylase gene family. UTX can demethylate H3K27; however, in vitro assays suggest that human UTY has lost enzymatic activity due to…
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Highly cooperative chimeric super-SOX induces naive…
Sox2/Oct4 dimerization emerged as the core driver of naive pluripotency with its levels diminished upon priming. Transient overexpression of the SK cocktail (Sox+Klf4) restored the dimerization and boosted the developmental potential of…
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Musikåret 2005 – Wikipedia
Vänligen sortera soloartister på efternamn, musikgrupper på förstabokstaven (utan engelskans "The" och "A")
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Small Molecule Proteostasis Regulators for Protein…
Protein homeostasis (proteostasis) is essential for cellular and organismal health. Stress, aging, and the chronic expression of misfolded proteins, however, challenge the proteostasis machinery and the vitality of the cell.
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The CRTC1-SIK1 Pathway Regulates Entrainment of the Circadian…
Retinal photoreceptors entrain the circadian system to the solar day. This photic resetting involves cAMP response element binding protein (CREB)-mediated upregulation of Per genes within individual cells of the suprachiasmatic nuclei (SCN…
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Rhythmic PER abundance defines a critical nodal point for…
Circadian rhythms in mammals are generated by a transcriptional negative feedback loop that is driven primarily by oscillations of PER and CRY, which inhibit their own transcriptional activators, Clock and BMAL1.
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Teresa Southard | Associate Clinical Professor | PhD, DVM…
Teresa Southard, Associate Clinical Professor | Cited by 1,962 | of Cornell University, Ithaca (CU) | Read 56 publications | Contact Teresa Southard
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SOX2 - Wikipedia
Oct-4, Sox2 and Nanog positively regulate transcription of all pluripotency circuitry proteins in the LIF pathway. [7 ]
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