Zebrafish - Wikipedia
Native to South Asia, [3 ] it is a popular aquarium fish, frequently sold under the trade name zebra danio [4 ] (and thus often called a "tropical fish" although it is both tropical and subtropical).
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The dynamic interaction of Ambra1 with the dynein motor complex…
When autophagy is induced, ULK1 phosphorylates Ambra1, releasing the autophagy core complex from the cytoskeleton and allowing its relocalization to the ER membrane to nucleate autophagosome formation.
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Oncogenic and teratogenic effects of Trp53Y217C, an…
In a mouse model of the hotspot mutant TP53Y220C, the mutant p53 exhibited oncogenic gain of function in males and teratogenic gain of function in females, both correlated with inflammation.
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Pigmentation PAX-ways: The role of Pax3 in melanogenesis…
Transcription factors initiate a program of gene expression and are catalysts in downstream molecular cascades that modulate a variety of cellular processes. Pax3 is a transcription factor that is important in the melanocyte and influences…
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Iron deficiency impairs developing hippocampal neuron gene…
Iron deficiency (ID), with and without anemia, affects an estimated 2 billion people worldwide. ID is particularly deleterious during early-life brain development, leading to long-term neurological impairments, including deficits in
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AKT/PKB Signaling: Navigating Downstream - PMC
The serine/threonine kinase Akt, also known as protein kinase B (PKB), is a central node in cell signaling downstream of growth factors, cytokines, and other cellular stimuli. Aberrant loss or gain of Akt activation underlies the…
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CREB-binding protein/p300 are transcriptional coactivators of p…
CBP (CREB-binding protein) and p300 are versatile coactivators that link transcriptional activators to the basal transcriptional apparatus. In the present study, we identify CBP and p300 as coactivators of the nuclear factor-κB (NF-κB…
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Samir El Andaloussi | Karolinska Institutet
Leader of exosome research. Professor of Biomolecular Medicine and Advanced Therapy at Karolinska Institutet since 1 November 2021.
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mir-17 microRNA precursor family - Wikipedia
The microRNA precursor miR-17 family, includes miR-20a/b, miR-93, and miR-106a/b. With the exception of miR-93, these microRNAs are produced from several microRNA gene clusters, which apparently arose from a series of ancient evolutionary…
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p53 upregulated modulator of apoptosis - Wikipedia
The p53 upregulated modulator of apoptosis (PUMA) also known as Bcl-2-binding component 3 (BBC3), is a pro-apoptotic protein, member of the Bcl-2 protein family. [5 ] [6 ] In humans, the Bcl-2-binding component 3 protein is encoded by the…
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