BRCA2 - Wikipedia
BRCA2 contains a number of 39 amino acid repeats that are critical for binding to RAD51 (a key protein in DNA recombinational repair) and resistance to methyl methanesulphonate treatment. [102 ] [109 ] [110 ] [118 ]
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Role of natural compounds in preventing and treating breast…
Breast cancer (BrCa) is the most commonly diagnosed cancer and the second leading cause of cancer-related death in women. Alarming increases in the cases quests for more effective treatment of BrCa.
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Mechanisms of inherited cancer susceptibility - PMC
A small proportion of many cancers are due to inherited mutations in genes, which result in a high risk to the individual of developing specific cancers. There are several classes of genes that may be involved: tumour suppressor genes…
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Carcinogenesis - Wikipedia
Only certain mutations lead to cancer whereas the majority of mutations do not.[ citation needed]
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Resveratrol Prevents Epigenetic Silencing of BRCA-1 by the…
The BRCA-1 protein is a tumor suppressor involved in repair of DNA damage. Epigenetic mechanisms contribute to its reduced expression in sporadic breast tumors. Through diet, humans are exposed to a complex mixture of xenobiotics and…
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Biomarkers Predicting Progression and Prognosis of Ductal…
However, several transcriptomic changes in the luminal epithelium may play a role in cancer hallmarks. These include genes involved in cell cycle control [MKI67 (Ki-67), CDNK2A (p16), Aurka (Aurora kinase A), BCL9 (B-cell CLL/lymphoma 9…
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Akt: A Double-Edged Sword in Cell Proliferation and Genome…
The Akt family of serine/threonine protein kinases are key regulators of multiple aspects of cell behaviour, including proliferation, survival, metabolism, and tumorigenesis. Growth-factor-activated Akt signalling promotes progression…
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Histone deacetylase inhibitors (Hdacis): multitargeted…
Histone deacetylase (HDAC) inhibitors are an emerging class of therapeutics with potential as anticancer drugs. The rationale for developing HDAC inhibitors (and other chromatin-modifying agents) as anticancer therapies arose from the…
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Cell-Cycle Regulation in Embryonic Stem Cells: Centrosomal…
Embryonic stem cells seem to have the intriguing capacity to divide indefinitely while retaining their pluripotency. This self-renewal is accomplished by specialized mechanisms of cell-cycle contro.
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Chiquita banana and blueberry breakfast muffins | Chiquita
Craving for a healthier muffin that does not give up on flavour? These muffins are a tasty and healthy kickstart of your day.
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