Full professor at the Department of Pharmacy and Biotechnology and member of the PhD Committee in Cellular and Molecular Biology, my research activity mainly focuses on cellular, molecular and epigenetic mechanisms of neuron-glia…
Maintenance of skeletal muscle mass is contingent upon the dynamic equilibrium (fasted losses–fed gains) in protein turnover. Of all nutrients, the single amino acid leucine (Leu) possesses the most marked anabolic characteristics in acting…
Acute alcohol (EtOH) intoxication decreases muscle protein synthesis via inhibition of mTOR-dependent translation initiation. However, these studies have been performed in relatively young rapidly growing rats in which muscle protein…
Chronic liver diseases pose a substantial health burden worldwide, with approximately two million deaths each year. Branched-chain amino acids (Bcaas)—valine, leucine, and isoleucine—are a group of essential amino acids that are essential…
The aggregation of abnormally folded proteins is a defining feature of neurodegenerative disease, but it has not previously been possible to assess the conformation of these proteins in a physiologically relevant context, before they form…
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