Different plants of the genus Cannabis contain different and often unpredictable concentrations of THC and other cannabinoids and hundreds of other molecules that have a pharmacological effect, [2 ] [3 ] so the final net effect cannot…
Of cannabidiol (CBD) to tetrahydrocannabinol (THC) can occur through a ring-closing reaction. [1 ] [2 ] [3 ] This cyclization can be acid-catalyzed [4 ] or brought about by heating. [5 ] [6 ] [7 ] [8 ] [9 ] [10 ] [11 ]
Cannabis has been used medicinally for millennia, but has not been approved by the U.S. Food and Drug Administration to treat any medical condition. Cannabinoids are the components in cannabis; some are commercially available to treat…
Medical cannabis, medicinal cannabis or medical marijuana (MMJ) refers to cannabis products and cannabinoid molecules that are prescribed by physicians for their patients. [1 ] [2 ] [3 ] [4 ] The use of cannabis as medicine has a long…
The entourage effect is a hypothesis that cannabis compounds, other than the cannabinoids tetrahydrocannabinol (THC) and cannabidiol (CBD), act synergistically with cannabinoids to modulate the overall psychoactive effects of the plant. [1…
The cannabinoid receptor 1 (CB1) is the principal target of the psychoactive constituent of marijuana, the partial agonist Δ9-tetrahydrocannabinol (Δ9-THC)1. Here we report two agonist-bound crystal structures of human CB1 in complex with a…
Introduction: Cannabis biosynthesizes Δ9-tetrahydrocannabinolic acid (THCA-A), which decarboxylates into Δ9-tetrahydrocannabinol (THC). There is growing interest in the therapeutic use of THCA-A, but its clinical application may be hampered…