In the past few years, Bruton’s tyrosine Kinase (Btk) has emerged as new target in medicinal chemistry. Since approval of ibrutinib in 2013 for treatment of different hematological cancers (as leukemias and lymphomas), two other…
Microglia possess varied morphologies and functions. Under normal physiological conditions, microglia mainly exist in a resting state and constantly monitor their microenvironment and survey neuronal and synaptic activity.
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A comprehensive characterization of neuronal cell types, their distributions and patterns of connectivity is critical for understanding the properties of neural circuits and how they generate behaviors.
Seznam publikací: CLIP / spolupráce 2025 Seferna K, Svaton M, Rennerova A, Skotnicova A, Reznickova L, Valova T, Sedlacek P, Riha P, Formankova R, Keslova P, Sramkova L, Stary J, Zuna J, Kolenova A, Salek C, Trka J, Fronkova E.
Since its discovery two decades ago, the activation of the JAK/STAT pathway by numerous cytokines and growth factors has resulted in it becoming one of the most well studied intracellular signalling networks.