ADAM9 Inhibition Increases Membrane Activity of ADAM10 and…

Background: Raising ADAM10 α-secretase activity has been considered as an attractive therapeutic option in Alzheimer disease. Results: Administration of the prodomain of ADAM9 (proA9) prevents ADAM10 shedding and increases membrane α…
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Neuronal sorting protein-related receptor sorLA/LR11 regulates…

SorLA (sorting protein-related receptor) is a type-1 membrane protein of unknown function that is expressed in neurons. Its homology to sorting receptors that shuttle between the plasma membrane, endosomes, and the Golgi suggests a related…
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Sortilin Controls Intracellular Sorting of Brain-Derived…

Crude lysates were immunoblotted with sortilin antibodies and HA antibodies to confirm equivalent expression level (bottom).
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Sortilin-Mediated Endocytosis Determines Levels of the Fronto…

The most common inherited form of Fronto-Temporal Lobar Degeneration (FTLD) known stems from Progranulin (GRN) mutation, and exhibits TDP-43 plus ubiquitin aggregates. Despite the causative role of GRN haploinsufficiency in FTLD-TDP, the…
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A Hellenistic Bibliography - Ovid

The Dialectic of Opposing World Views in the Expansion of the Epic Literary Genre (Homer, Dante, Milton). University of Pennsylvania, Philadelphia, 1985, 239 pp.
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Furin AT THE Cutting EDGE: FROM Protein Traffic TO…

Furin catalyses a simple biochemical reaction – the proteolytic maturation of proprotein substrates in the secretory pathway. But the simplicity of this reaction belies furin's broad and important roles in homeostasis, as well as in…
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Sorla/SORL1 Functionally Interacts with SPAK To Control Renal…

Proper control of NaCl excretion in the kidney is central to bodily functions, yet many mechanisms that regulate reabsorption of sodium and chloride in the kidney remain incompletely understood.
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Genomic insights into members of the candidate phylum Hyd24-12…

AbstractMembers of the candidate phylum Hyd24-12 are globally distributed, but no genomic information or knowledge about their morphology, physiology or ec
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Kliniken Dr. Erler - ANOA-Kliniken e.V.

Als Teilbereich der Wirbelsäulentherapie hat sich die Behandlung nach dem ANOA-Konzept unter der Leitung der Dres. med. Kübrich und Knoll auf die interdisziplinäre Zusammenarbeit aller verfügbaren Fachabteilungen spezialisiert und…
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EurekaMag Full Text Articles Chapter 10494

Full Text Articles available from EurekaMag Chapter 10494
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