Background: Raising ADAM10 α-secretase activity has been considered as an attractive therapeutic option in Alzheimer disease. Results: Administration of the prodomain of ADAM9 (proA9) prevents ADAM10 shedding and increases membrane α…
SorLA (sorting protein-related receptor) is a type-1 membrane protein of unknown function that is expressed in neurons. Its homology to sorting receptors that shuttle between the plasma membrane, endosomes, and the Golgi suggests a related…
The most common inherited form of Fronto-Temporal Lobar Degeneration (FTLD) known stems from Progranulin (GRN) mutation, and exhibits TDP-43 plus ubiquitin aggregates. Despite the causative role of GRN haploinsufficiency in FTLD-TDP, the…
The Dialectic of Opposing World Views in the Expansion of the Epic Literary Genre (Homer, Dante, Milton). University of Pennsylvania, Philadelphia, 1985, 239 pp.
Furin catalyses a simple biochemical reaction – the proteolytic maturation of proprotein substrates in the secretory pathway. But the simplicity of this reaction belies furin's broad and important roles in homeostasis, as well as in…
Proper control of NaCl excretion in the kidney is central to bodily functions, yet many mechanisms that regulate reabsorption of sodium and chloride in the kidney remain incompletely understood.
AbstractMembers of the candidate phylum Hyd24-12 are globally distributed, but no genomic information or knowledge about their morphology, physiology or ec
Als Teilbereich der Wirbelsäulentherapie hat sich die Behandlung nach dem ANOA-Konzept unter der Leitung der Dres. med. Kübrich und Knoll auf die interdisziplinäre Zusammenarbeit aller verfügbaren Fachabteilungen spezialisiert und…