19. 12. 2010Wroclaw - Přesné příčiny nemoci mozku způsobující u desítek milionů lidí předčasnou demenci zatím nikdo neobjevil. Neexistuje proti tomu zatím ani žádný lék. Znám je však německý psychiatr a neuropatolog, který změny v mozkové kůře jako…
Alois Alzheimer (/ ˈ ɑː l t s h aɪ m ər/ Ahlts-hy-mər, [1 ] German: [ˈaːlɔɪs ˈʔaltshaɪmɐ]; 14 June 1864 – 19 December 1915) was a German psychiatrist, neuropathologist and colleague of Emil Kraepelin.
Neurolog a vědec Martin Tolar říká, že podle některých odhadů se Alzheimerova nemoc rozvíjí až u 1,2 milionu Čechů, kteří o tom nevědí, jsou v tzv. preklinickém stadiu a říká ...
Alzheimer's disease (AD) has been identified as a proteopathy: a protein misfolding disease due to the accumulation of abnormally folded amyloid beta (Aβ) protein in the brain. [1 ] Amyloid beta is a short peptide that is an abnormal…
Since 1992, the amyloid cascade hypothesis has played the prominent role in explaining the etiology and pathogenesis of Alzheimer's disease (AD). It proposes that the deposition of β-amyloid (Aβ) is the initial pathological event in AD…
In this Seminar, we highlight the main developments in the field of Alzheimer’s disease. The most recent data indicate that, by 2050, the prevalence of dementia will double in Europe and triple worldwide, and that estimate is 3 times higher…
Since the original publication describing the illness in 1907, the genetic understanding of Alzheimer’s disease (AD) has advanced such that it is now clear that it is a genetically heterogeneous condition, the subtypes of which may not…
Alois Alzheimer might have mentioned plaques and tangles in a single short paper on pre-senile dementia in 1907, but it was the co-discover of Alzheimer’s disease (AD), Oskar Fischer, who in that same year far more extensively reported…
This technique has provided evidence for significant thinning of the peripapillary NFL, macular volume loss, and nerve fiber density decrease in patients with mild to severe AD, suggesting that thinning might occur early in disease…