Whole genome sequencing (WGS), also known as full genome sequencing or just genome sequencing, is the process of determining the entirety of the DNA sequence of an organism's genome at a single time. [2 ] [3 ] [4 ] This entails sequencing…
E. coli that cause neonatal meningitis largely derive from two global clonal lineages that can additionally form intestinal reservoirs to seed recrudescent invasive infection even when appropriate antibiotics are used.
Nuclear retinoic acid receptors (RARs) are transcriptional regulators controlling the expression of specific subsets of genes in a ligand-dependent manner. The basic mechanism for switching on transcription of cognate target genes involves…
Peroxisome-proliferator activator receptor γ (Pparγ) is a nuclear receptor of central importance in energy homeostasis and inflammation. Recent experimental pieces of evidence demonstrate that Pparγ is implicated in the oxidative stress…
In this pre-clinical in vitro study conducted in estrogen receptor positive (ER+) breast cancer cells, we have characterized the effects of insulin-like growth factor I (IGF-1) on the cytostatic and cytotoxic action of antiestrogen…
Před 5 měsíciKdyž satelitu na orbitě dojde palivo, je konec, i když je jinak v dobrém stavu. Zachránit je mohou servisní satelity MEV, které se připojí k dotyčnému satelitu a nahradí jeho pohon.
Skeletal and cardiac muscles play key roles in the regulation of systemic energy homeostasis and display remarkable plasticity in their metabolic responses to caloric availability and physical activity.
Complex organisms require tissue-specific transcriptional programs, yet little is known about how these are established. The transcription factor FoxA1 is thought to contribute to gene regulation though its ability to act as a pioneer…
Společně s družkou Clark Madison s jejími dětmi Nickem a Alicii, byvalou Travisovou manželkou Lizou Ortiz, jejich synem Christopherem a dalšími se snaží přežít pandemii chodících mrtvých, která vypukla.